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Persistent accumulation of activated myofibroblasts within lesional tissue, the hallmark of SSc and other forms of fibrosis, is induced by transforming growth factor- (TGF-), interleukin-6 (IL-6), and a host of other soluble factors 3,8

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It is available through compounding pharmacies for investigational and clinical off-label use, but it should only be sourced through a licensed, reputable compounding pharmacy under physician oversight