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HRMVECs were treated with increasing concentrations of D-glucose (25, 50, 100, and 150 mM), and the control group with mannitol in the same concentrations

Mar 2004;87(3):255-263

And this NADPH is important for regenerating glutathione, which is a tripeptide antioxidant that our bodies use to protect against highly energetic Reactive Oxygen Species (ROS) that, if left unchecked, can attack our proteins, lipids, etc

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Specifically, the prefrontal cortex (PFC) exhibited notable alterations, including a marked increase in 1,2-diacylglycerol (DG) levels