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Ewa, PK, Giulia, N, Florent, D, Damarys, L, Patrick, P, Yi, X, Kopetz, S , Jennifer, D, Lucie, P, Catherine, RM, Philippe, S, Patrick, TC, Shaynoor, D

The tryptophan 5-hydroxylase 1, crucial for the synthesis of serotonin (5-HT), and tyrosine hydroxylase, a rate-limiting enzyme in the production of dopamine, adrenaline, and noradrenaline, are both positively regulated by SCFAs (175, 176)

In Embodiment 70 of this disclosure are compounds of Formula or any one of Embodiments 1-69, or a pharmaceutically acceptable salt of any of the foregoing, wherein X and Y are C(R 5 )