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In melanoma cells, curcumin can cause time and dose-dependent apoptosis that is not dependent on p53 activation

For instance, weak growth hormone signaling may exacerbate muscle wasting in midlife and alter fat distribution, which loops back to hormone levels via adipose-derived estrogen

doi: 10.1002/ajh.24088 25 GrayL

Kuan, Kah-Tiong

thaliana , overexpressed NRAMP6 resulted in Cd hypersensitivity through increased Cd uptake, while nramp6 loss of function mutants resulted in reduced Cd uptake leading to increased plant tolerance when exposed to high levels of Cd ( NRAMP5 resulted in reduced Cd accumulation in roots and leaves (Sasaki et al., 2012)