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HGF can upregulate the transcription factor Ets-1, thus enhancing the expression of vascular endothelial growth factors (VEGFs) (Tomita et al., 2003)

Data are from the on-treatment observation period (during treatment with trial product [any dose of trial medication administered within the previous 49 days (that is, any period of temporary treatment interruption with trial product was excluded))

[DOI] [PubMed] [Google Scholar] 34.Tan TM, Field BCT, McCullough KA, Troke RC, Chambers ES, Salem V, et al

Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML

These formulations have different affinities to key proteins and receptors which facilitate the generation of biologically active intracellular cobalamin and thus, differ in their rates of tissue retention and bioavailability (Paul and Brady, 2017)