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In conclusion, current clinical data is not yet sufficient to provide systematic therapeutic protocols and future large-scale studies on individuals with AD are required to validate the present findings

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Conversely, more recent studies in bronchiectasis patients, including CF cohorts, reported decreased plasma SOD activity, potentially from increased consumption due to heightened extracellular superoxide, reduced synthesis, or impaired EC-SOD release (Olveira et al., 2013)