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DEGseq was used to identify differentially expressed genes in macrophages and enrichment analysis was performed(SeqHealth, Wuhan)

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Pediatr Res (2004) 56(2):21926

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Nonetheless, it is intriguing that elevation of inflammatory cytokines in the CNS has been associated with suppressed synthesis of neurotrophic factors (especially BDNF) and compromised monoaminergic transmission (204), both of which have been reported in bipolar disorder