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Moreover, Both treatment groups showed a noteworthy reduction in MASI score from the baseline (Manfreda et al., 2023)

Notably, lignans exhibit anti-cancer activity through multiple regulatory pathways ( 3 Factors affecting the appropriate extraction methods for phenolic compounds Polyphenols comprise a broad array of chemical structures, resulting in varied chemical and physical properties ( Furthermore, extraction efficiency is highly sensitive to operational parameters such as pH, type of solvent employed, solvent-to-sample ratio, and duration of the extraction process ( 3.1 Extraction methods of phenolic compounds 3.1.1 Ultrasound-assisted extraction method Ultrasound-assisted extraction is a widely used and efficient technique for isolating phenolic compounds, offering high yields in a relatively short time ( The process relies on acoustic cavitation, wherein ultrasonic waves disrupt plant cell walls by inducing rapid expansion and contraction of solid surfaces ( Randia monantha , mango seed kernels, olive pomace, and pine needles ( Ultrasound-assisted extraction provides notable advantages for the extraction of polyphenols

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Another essential key role of glutathione for skin whitening is regulating melanin production by inhibiting the enzyme tyrosinase, which is involved in the synthesis of melanin, which may contribute to skin lightening

For deeper concerns like melasma, 812 sessions may be necessary, sometimes combined with peels or glutathione infusions