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doi: 10.1165/ajrcmb.17.5.2833

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Clin Pract (2020) 10(2):1271

However, in some metabolic disorders, Parp2 -knockout mice showed enhanced SIRT1 activity and improved metabolic functions, and were protected against high-fat diet-induced obesity, which were not due to augmented NAD + levels, but to an increase in SIRT1 expression, as PARP2 acts as a direct negative regulator of the SIRT1 promoter [59]

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