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5.4 Safety and Comfort Because force and displacement are meticulously calculated, patients report the adjustment as barely noticeable yet immediately soothing. There are virtually no contraindications aside from acute cervical fractures or severe osteoporosiswhich are screened out by thorough history and imaging

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However, some studies have utilised between 8 and 24 h to represent the colon [68, 69], because there is a large intra-individual variation in small intestinal transit time (from 50460 min) [70]