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Emerging strategies include selecting efflux-insensitive payloads like topoisomerase I inhibitors, as demonstrated by T-DXds success in DESTINY-CRC01, contrasting with MMAE-based failures (122)

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Our data confirm that sKL concentrations increase with rGH therapy, but remain within the comparably broad reference interval seen in healthy subjects

These medications may include tranquilizers, anti-seizure medications, sedatives, antipsychotics, and sleep aids

Table 2 summaries the microbial metabolites of EC that have demonstrated anti-inflammatory effects, along with their precursors, experimental models, and underlying mechanisms