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Glutamate is the most abundant neurotransmitter in the central nervous system, and extracellular glutamate receptors can be found at the synaptic site of neurons, astrocytes, oligodendrocytes, or microglia

Standard care for diabetes and cardiovascular disease simultaneously was also provided to patients

In this setting, PARP inhibitors preserve intracellular NAD + and ATP levels, attenuate oxidative and inflammatory damage, and limit cardiomyocyte death, leading to reduced infarct size and improved post-ischemic functional recovery in experimental models

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