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Collectively, the results of this study illustrate that AOD9604 exerts distinct metabolic effects depending on the genetic background of the animal and the presence of functional 3-ARs

Microglial cells are capable of differentiating into distinct functional states, including the M1 phenotype, which exerts pro-inflammatory and neurotoxic effects, and the M2 phenotype, which is linked to anti-inflammatory and neuroprotective actions 58

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