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Given that obesity is a chronic and relapsing disease, it is important to understand the effectiveness of different strategies to maintain WL: TRIUMPH-6 (NCT06859268) will assess changes in bodyweight at 116 weeks in individuals with obesity who have completed 80 weeks of retatrutide, comparing continued treatment at high or low doses of retatrutide versus switching to placebo for the last 36 weeks

While no formal clinical trials have established optimal combined dosing, synthesis of available research and community experience provides practical guidance

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Examples are anastrozole, letrozole, tamoxifen, clomiphene, and GW501516 (Cardarine), meldonium, and trimetazidine