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Only opioid-receptor-active peptides and a narrow category of scheduled substances require BfArM licensing [2]

For example, production of the neurotransmitter, 5-HT/serotonin, was reportedly upregulated in the presence of spore-forming Clostridia species , while germ-free mice displayed lower 5-HT/serotonin levels in their colon and blood as well as reduced intestinal motility (Kashyap et al