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Figure 2 3.1 Activation of inflammatory signaling pathways Research indicates that increased intestinal permeability allows endotoxins such as LPS to enter the systemic circulation, where they trigger systemic inflammatory responses by activating the Toll-like receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells (TLR4/NF-B) inflammatory pathway

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0.8 g/kg/day: HR = 0.73), with both plant and animal protein showing protective effects

However, a key problem of drug repurposing is the lack of single-agent activity, its feasibility should be examined in further studies (112)

INH + CC-11050 treatment was more efficient than isoniazid alone in terms of increased MTB clearance efficiency, and the inflammatory state was suppressed, as evidenced by the downregulation of inflammatory factors such as TNF-