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Although targeting RIPK3 is a novel and promising therapeutic approach for NAFLD/NASH and HCC, it is crucial to consider that inhibiting necroptosis should not inadvertently activate other alternative cell death pathways in clinical practice

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When combined with alpha-lipoic acid, some early research has shown that benfotiamine may enhance effects in reducing pain and improving nerve conduction in people with diabetic neuropathy.8 The synergy likely stems from their complementary mechanisms: benfotiamine helps manage glucose-induced damage, while ALA reduces oxidative stress and improves blood flow

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Luo JL, Hammarqvist F, Andersson K