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Iron accumulation drives the Fenton and Haber-Weiss reactions, generating ROS that induce lipid peroxidation, leading to oxidative damage to subcellular structures (88)

Moreover, functionalized NPs can act as contrast agents in imaging techniques, selectively accumulating in affected brain areas to enhance disease detection and monitoring (126)

Notably, Gln deprivation significantly reduced the expression of CCNB1, CDK1 and p-CDK1 in HCC and PCa cells (Fig

Glutathione represents the most abundant intracellular antioxidant capable of (i) directly interacting with free radical species, (ii) revitalizing other small molecule antioxidants (e.g., vitamins C or E), (iii) maintaining the redox state of protein thiols, and (iv) serving as a cofactor for enzymes of the cellular antioxidant system (Espinosa-Diez et al

(2014) measured the hydrogen concentration in the tissues of rats that ingested hydrogen through different methods and found that oral and intraperitoneal injections can achieve higher hydrogen concentrations in multiple organs, while hydrogen inhalation results in elevated concentrations in muscle and brain tissues