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Those with Celiac disease, Crohns, or other gut disorders, and those taking drugs to calm heartburn, like omeprazole, have difficulty absorbing B12

Many individuals in Australia prefer the convenience of an over the counter solution that provides clear guidance for use

[95] Intramuscular or intravenous injection [edit] Injection of hydroxycobalamin is often used if digestive absorption is impaired, [2] but this course of action may not be necessary with high-dose oral supplements (such as 0.51.0 mg or more), [97] [98] because with large quantities of the vitamin taken orally, even the 1% to 5% of free crystalline B 12 that is absorbed along the entire intestine by passive diffusion may be sufficient to provide a necessary amount

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Slow injection reduces foam formation during solution preparation steps