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[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function

One of the reasons we love AOD 9604 is that clinical trials have shown it to be very well-tolerated, with no significant impact on blood sugar, insulin levels, or IGF-1

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It improves glucose metabolism in skeletal muscle, which implies a number of benefits for those with diabetes, obesity, or who are over 30 years old