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Tian T, Wang Z, Zhang J

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Vascular endothelial cells, smooth muscle cells and extracellular matrix gradually change, resulting in reduced endothelial function, a thickened intima, vascular sclerosis, increased arterial pressure, reduced number of capillaries and decreased permeability, which further cause tissue ischemia and hypoxia, oxidative stress damage and necrosis (7, 8)

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