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At Perfect B in Doral, those three factors are the starting point, not an afterthought

These components can activate the Nrf2 antioxidant pathway, upregulate the expression of antioxidant enzymes such as SOD and GSH-Px, and protect the activity of the CYP450 metabolic enzyme system

doi: 10.1001/archfaci.7.1.27

Therefore, these aforementioned compounds represent promising skin-whitening agents, but those targeting TYR gene expression are not recommended for clinical use mainly for their non-specific effects through intracellular signaling cascades (73)

5.3 Human evidence of transgenerational effects Although human data documenting transgenerational EED effects remain limited due to the extended timeframes required for multigenerational studies, emerging evidence provides preliminary support for intergenerational inheritance of reproductive impairments