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Additionally, the administration of curcumin has demonstrated therapeutic potential by negatively regulating various signaling pathways (PI3/Akt, JAK/STAT, and -catenin), inhibiting the expression of COX-2, iNOS, and co-stimulatory molecules (RANKL, ICAM-1, CD205, CD256, TLR4, among others), and suppressing immune cell chemotaxis, including the infiltration of neutrophils into inflamed regions (Zhao et al., 2016

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Ethics declarations Competing interests The corresponding author Guang-ji Wang is a member of the Editorial Board of the journal Acta Pharmacologica Sinica, but he has not been involved in the peer-review or decision-making process for this manuscript

Variants of MTHFR , which is a critical enzyme for intracellular folate homeostasis and metabolism, were reported to be associated with elevated circulating homocysteine levels and many diseases including PCa

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