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Description

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

Here, we reported an interdisciplinary study of AKAP11 neuronal function and the consequence of the loss-of-function in AKAP11 in both genetic mouse models and human pluripotent stem cell (PSC)-induced neurons (iNeurons) by integrating multi-omics, cell biology, and electrophysiology approaches