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The risk of systemic copper overload is negligible when used topically at recommended concentrations

Nuclei were labeled with DAPI (blue)

10.18632/aging.100252 Aging 188 HaigisM

Melanin, produced by melanocytescells located within the skindetermines our skin tone and its color

Chem Res Toxicol 21(2):550553 Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT (2008) RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation