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A case-control study (50 domestic shorthair cats with a confirmed diagnosis of FISS and 100 disease-free matched controls) investigating a possible association between polymorphisms in the genomic sequence of the feline p53 gene and a predisposition to FISS, found a strong association between FISS and the presence of specific nucleotides at two of the polymorphic sites (Banerji et al., 2007)

10.1016/j.molcel.2018.10.042 25 GkouvatsosK.PapanikolaouG.PantopoulosK

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However, this idea was to some extent supported by the finding of somewhat more pronounced phenotypes in double and triple knock-out animals (30)