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In a variety of heart diseases, the regenerative ability of cardiomyocytes after injury is weak

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The excessive use of glucose for energy production makes the brain especially susceptible to oxidative stress, and mitochondrial ETC is the primary ROS source (Cobley et al., 2018)

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In 2024 the FDA approved a biologics license application (BLA) for the investigational T-cell therapy afamitresgene autoleucel (afami-cel,Tecelra ), targeting MAGE- A4 antigen, in the management of advanced synovial sarcoma (57, 58)