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The hypothalamus governs when those pulses occur through two opposing signals: GHRH (growth-hormone-releasing hormone), which stimulates release, and somatostatin, which suppresses it

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The longer half-life is the reason once-daily dosing is the standard schedule across research-community protocols

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The increase in liver size (liver:body weight ratio) could be explained by the increase in circulating GH as a result of the lack of the IGF-1-mediated negative feedback mechanism, where circulating IGF-1 produced by the liver can regulate secretion of GH and consequently the size of the liver (164, 309311)

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