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Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

Bcl-2 / Bax ratio A molecular "survival score." Bcl-2 is an anti-apoptotic protein that protects cells from death

In the NOR test, there was no difference in the time spent exploring the left and right objects during the training phase among the groups (Fig