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Other common causes of vitamin B12 deficiency include gastrectomy, ileal resection, pancreatic insufficiency and malabsorption syndromes including Crohns disease and coeliac disease. The bottom line : for patients with the above gastrointestinal challenges, getting enough B12 into the bloodstream through oral supplementation is not possible

doi:10.1177/02601060221144801

The synthesis constitutes a formal total synthesis, since the research groups only prepared the known intermediate cobyric acid, whose chemical conversion to vitamin B 12 was previously reported

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