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According to PRISMA guideline, the systematic review was performed, and the meta-analysis was performed using random-effect model

Like other polyphenols, Sal A can accept methyl groups from SAM and cause an elevation of homocysteine during the methionine-homocysteine cycle (Figure 1) [20]

The most extensive investigation to date into polymorphisms of genes encoding enzymes needed for estrogen metabolism and estrogen receptors as well as SNP associations with vasomotor symptoms and cardiovascular risk parameters is the Study of Women Across the Nation (SWAN)