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Upon activation, free radicals such as nitric oxide (NO) and superoxide are released, which elevates oxidative stress contributing to pathogen elimination and local tissue damage ( Migraine Pathogenesis: Role of Oxidative Stress, Neuroinflammation, and Mitochondrial Dysfunction Migraine is defined as a neurovascular disorder involving cortical spreading depression (CSD), neurogenic inflammation, and dysfunction in cranial vascular contractility ( Oxidative Stress Oxidative stress role in migraine pathogenesis is emphasized by multiple studies

Although some terrestrial animals traveling by foot can travel great distances, walking uses more energy compared to flying or swimming, especially when passing through adverse conditions

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10.1038/s41531-021-00213-7 NPJ Parkinsons Dis