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All procedures were in accordance with the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals and approved by the University of Arkansas for Medical Sciences Institutional Animal Care and Use Committee (IACUC#3551)

The decrease in NO increases the expression of transcription factor nuclear factor kappa B (NF- B) which serves to increase synthesis of cytokines and adhesion molecules

In addition, there are currently a few studies investigating the effects of other bisphenols on the gut microbiota

However, factors like stress, aging, and toxins can deplete its levels

Side Effects and the Copper Uglies Explained GHK-Cu has a strong safety profile in topical research, but a small subset of users experience a transient phase known as the copper uglies. A 2023 clinical safety review covering 12 studies and 512 participants reported that the most common side effects of topical GHK-Cu were transient and mild