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Five studies of BPC-157 reviewed by the agency "were of short duration, had small sample sizes and evaluated doses that were likely exploratory in nature," the staffers said

119 NaclerioRAnsoteguiIJBousquetJCanonicaGWDAmatoGRosarioNet al

The inclusion criteria emphasized the following: (1) Mechanistic studies that explore NACs neuromodulatory effectsspecifically its impact on oxidative stress, neurotransmission, and neuroinflammatory signalingin both in vitro and in vivo models

Combined with the anti-reflux benefits of weight loss, the long-term trajectory favors improvement

By addressing both the biological rationale and methodological limitations of existing studies, this review provides insight that could be used as a reference to inform clinical decision-making and support the development of robust, evidence-based guidelines for tinnitus management