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the inflation volume (mm, means SD) was assessed before and after application of spasmogens (histamine, serotonin, acetylcholine, bradykinine, i.v.) or NaBPC157 (10 minutes before repeated spasmogen application, i.v.)

The standard regimen involves: Loading doses without neurological involvement : 1 mg intramuscularly three times a week for 2 weeks [3] [8] Loading doses with neurological involvement : 1 mg intramuscularly on alternate days until no further improvement [3] [8] Maintenance therapy : 1 mg every 23 months for life in cases of pernicious anaemia or irreversible malabsorption (every 2 months if neurological involvement) [3] [8] This aggressive approach aims to prevent irreversible neurological damage, though recovery of established neuropathy may be incomplete, particularly if treatment is delayed

Because KPV remains largely investigational, no universally accepted therapeutic dosage currently exists

Surgery is for people who have struggled to lose weight with other treatment methods