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The field requires comprehensive single-cell resolution mapping of AT microenvironments, longitudinal studies tracking dysfunction development from early metabolic stress to established disease, and systems-level integration of multi-omics data to identify causal relationships in metabolic regulation

- no significant effect

[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Armenian P., Gerona R.R., Blanc P.D., Wu A.H., Mookherjee S

Notably, by directly depleting SLC7A11, p53 decreases the activity of xCT to boost ferroptosis[151]