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As for L-NAME and/or L-arginine, we noted: L-arginine (100 mg/kg i.p.)rats: more bleeding, less/no thrombocytopenia

It has recently been demonstrated that in many cancer cell lines, including leukemia (L1210FR), ovarian (Ov2008, ID8), colon (Colo-26), mastocytoma (P815), lung (M109), renal (RENCA, RD0995), and breast (4T1, JC, MMT06056) cancer cell lines, biotin receptors are overexpressed more than folate and/or vitamin B-12 receptors (155, 156)

The reviewer AC declared a shared affiliation, with no collaboration, with one of the authors, AB, to the handling Editor at the time of the review