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The accumulation of inflamed tissue might progress into fibrosis in SG

Orthomolecular Medicine, 2001, 16(3):177-182 We demonstrated that ascorbate administration in guinea pigs reduced tumor growth rates, and that intra-tumor concentrations in the millimolar range were attained

This complements the traditional GSH-GPX4 pathway to collaboratively suppress phospholipid peroxidation and inhibit ferroptosis

Together our findings extend our understanding of CBS enzyme regulation, and open new avenues for investigating the pathogenic mechanism and therapeutic opportunities for CBS-associated disorders

As discussed, the interplay between astrocytes and microglia via modulation of GSH activity implies that GSH is not only a cellular antioxidant, but an important mediator of cross-talk between resident CNS immune cells