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Kang EA, Han YM, An JM, Park YJ, Sikiric P, Kim DH, et al

However, the relationships between levels of TSH, free T4 (FT4) and free T3 (FT3) are not the same in LT4-treated patients as in healthy, euthyroid individuals, and the distribution, metabolism and excretion of exogenous LT4 differ from those of endogenous T4 [23]

Moreover, cyclophosphamide (CTX) induces increased apoptosis and reduced cellular proliferation of GCs, and metformin can exert anti-apoptotic and cell proliferative effects against chemotoxicity via the AMPK-dependent p53 signaling pathway (Huang et al., 2021)