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Phases were retrieved by molecular replacement using Phaser-MR through the PHENIX graphical user interface with a known X-ray diffraction structure of papain determined to 1.65- resolution (PDB 9PAP) 76,77,78,81

It may influence the choice of folate supplement in some individuals, but it does not justify the conclusion that everyone with an MTHFR variant is unable to process folic acid

It is a public advisory process, one that could eventually lead to restored compounding access for some substances, but through a multi-step regulatory pathway that will take months possibly longer to resolve

Glutathione determination reaction was prepared using 700 L buffer KPE (0.1 M phosphate potassium, 0.001 M EDTA), 100 L cell extract, 60 L glutathione reductase solution (6 U/mL