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Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship

They are all ubiquitous except -butyrobetaine hydroxylase is absent from cardiac and skeletal muscle

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R 2 is selected from the group consisting of: hydrogen, ~ HPO(OY) 2 , " * ~ PO(OH) 2 , and - C(=0)-Y, where Y is -Z-(CH2)q-W-R b , q is 0-4, where Z and W are independently selected from the group consisting of: CH2, O, S, R C and R b , where R c is selected from the group consisting of: hydrogen, C1-C4 alkyl, and C3-C6 cycloalkyl, R b is selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C3-C8 cycloalkyl, C3-C8 substituted cycloalkyl, C3-C8 heterocycloalkyl, and C3-C8 substituted heterocycloalkyl, or alternatively -C(=0)-Y forms an amide bond thru a nitrogen atom on Y in which case Y is a selected from the group consisting of: glycine, sarcosine, ,-diemthyl glycine, alanine, valine, leucine, isoleucine, lysine, ornithine, arigine, serine, and theronine