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No therapeutic benefit was observed (Appendix Fig S4)
References Gagner, J.E., Shrivastava, S., Qian, X., Dordick, J.S., and Siegel, R.W.: Engineering nanomaterials for biomedical applications requires understanding the nano-bio interface: A perspective
Nutr Cancer 2013
Sustainability status of milk thistle Milk thistle is classified as least concern on the IUCN redlist due to stable populations in most of its native habitats and no major threats (17)
Based on the fact that IR and IGF-1R are abundantly expressed in chondrocytes 27,28 and the previous work which showed upregulation of IR signaling in osteoblasts lacking IGF-1R, 12 we suspected that the increased proliferation of IR-deficient growth plate chondrocytes could be caused by upregulation of the IGF-1/IGF-1R signaling pathway
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