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So far, we have identified POS as an adaptive physiological mechanism in 83 animal species from 8 different phyla when exposed to low oxygen stress and during estivation (Moreira et al., 2016, 2017)

Moreover, HIF2 KO cells showed enrichment of m + 15 proline isotopologues compared to both HIF WT and HIF1 KO cells (Figure S3D)

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The criterion exists because in clinical experience the predictable failure mode for peptide therapy is prescribing the second-best peptide for a patient whose presentation pointed to a different first choice