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A vitamin B12 deficiency can lead to pale skin and yellowing of the skin, called jaundice

Untreated pernicious anaemia also carries a greater risk of developing stomach cancer

This overwhelms the neuronal antioxidant defenses, causing oxidative damage to lipids, proteins, and DNA

Figure 5 SLC7A11 and cell death In the initial investigations into cell growth conditions, researchers observed that a lack of SLC7A11-mediated cystine transport proved fatal for certain cells ( Figure 6 )