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In brief, isopentenyl-pyrophosphate (IPP) is required for the synthesis of selenoproteins, including GPX4, and the isopentenylation of selenocysteine-tRNA stabilizes selenocysteine-specific tRNAs, contributing to ferroptosis suppression 105,127

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Kim ST, Chu Y, Misoi M, Suarez-Almazor ME, Tayar JH, Lu H, Buni M, Kramer J, Rodriguez E, Hussain Z, Neelapu SS, Wang J, Shah AY, Tannir NM, Campbell MT, Gibbons DL, Cascone T, Lu C, Blumenschein GR, Altan M, Lim B, Valero V, Loghin ME, Tu J, Westin SN, Naing A, Garcia-Manero G, Abdel-Wahab N, Tawbi HA, Hwu P, Oliva ICG, Davies MA, Patel SP, Zou J, Futreal A, Diab A, Wang L , Nurieva R