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Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial

Meanwhile, the reduction of beneficial bacteria (e.g., Bifidobacterium) results in insufficient production of short-chain fatty acids (SCFAs), which not only weakens their anti-inflammatory effects but also loses the inhibitory regulation on glycolysis, further breaking the balance (51, 52)

MOTs-C may pose significant risk for immunogenicity for some routes of administration, the agency said in 2023