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The number of treatments required depends on the severity of the condition being treated but typically four to six treatments are performed, with each one done one month apart

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For instance, in murine macrophages it has been shown that treatment with recombinant IL-10 induces, in a dose-dependent manner, HMOX1 production measured by Western Blot and that such an induction is mediated by the MAPK p38 activity (28), which is modulated by CO (29)