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Untreated vitamin B12 deficiencies can lead to neurological issues or pernicious anemia which can occur when your body does not have enough vitamin B12 to produce the amount of red blood cells it needs

A healthcare professional can prescribe vitamin B12 intramuscular injections or nasal gel spray for people with a severe vitamin B12 deficiency

[11] Serious side effects may include anaphylaxis, and low blood potassium resulting in heart failure

Here are some cases: A 52-year-old woman reacted to an intramuscular cyanocobalamin B12 shot, but later received oral B12 with no adverse effects

Why Vitamin B12 Matters Vitamin B12 plays a crucial role in how your body produces energy