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DVT pathogenesis is classically explained by Virchows Triad three interacting factors: Venous stasis (immobility, prolonged bed rest, long-haul travel, heart failure, obesity, paralysis) Endothelial injury (trauma, surgery, central venous catheters, prior DVT, vasculitis) Hypercoagulability (inherited thrombophilias Factor V Leiden mutation [D68.51], prothrombin G20210A mutation [D68.52], antiphospholipid syndrome [D68.61]

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The REDEFINE trials showed the combination produces approximately 22.7% body weight reduction, significantly more than either peptide alone

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