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Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1

In contrast, knockout of miR-221 results in elevated IGF-1 levels and enhances the proliferation of HF-KCs

Mol Cell Endocrinol , 198(1-2):8995

Metformin, as a ROS inhibitor, can maintain T cell activity by reducing intracellular ROS levels, thereby promoting tumor clearance and reducing tumor-associated inflammation [95]

In addition to a significantly higher rate of tracer leakage (218), tau oligomers and A were found to accumulate in the cerebral vessels of AD model mice (219), and eventually the mice developed cognitive decline